Long-term outcomes and quantitative comparison of mucosal repair using skin grafting versus polyglycolic acid sheet application for cT1-2 oral cancer defect

초록

Background Skin grafting and polyglycolic acid (PGA) sheet application are two established mucosal repair techniques for early-stage oral cancer defects, yet quantitative long-term comparative data are lacking.Aims and Objectives To compare long-term wound contracture and postoperative complications of two methods for cT1-2 oral cancer mucosal defects.Material and Methods In this retrospective cohort study, 53 patients who underwent mucosal repair with skin graft (n = 25) or PGA sheet (n = 28) were followed for long-term wound shrinkage (median, 40.0 months), graft failure/necrosis, postoperative bleeding, and tongue tethering.Results Wound area decreased to 25.0% (interquartile range [IQR], 15.5-36.3) of the initial defect in the skin graft group versus 12.6% (IQR, 9.2-17.9) in the PGA sheet group (p = 0.0019). Multivariable analysis identified PGA sheet application (p = 0.0015) and adjuvant radiation (p = 0.0056) as independent predictors of greater wound shrinkage. Postoperative bleeding (21.4% vs. 8.0%) and tongue tethering (32.1% vs. 8.0%, p = 0.043) were more frequent in the PGA sheet group.Conclusions and Significance Skin grafting offers superior long-term dimensional stability and fewer functional complications for cT1-2 oral cancer defects. PGA sheets may be preferred when operative time or donor-site morbidity is a priority, providing practical guidance for reconstructive planning. (sic)(sic) (sic)(sic)(sic)(sic)(sic)(sic)(sic)(PGA)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic), (sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic).(sic)(sic) (sic)(sic)(sic)(sic)cT1-2(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic).(sic)(sic)(sic)(sic)(sic) (sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic), 53(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(n=25)(sic)PGA(sic)(sic)(sic)(n=28)(sic)(sic)(sic)(sic)(sic), (sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)((sic)(sic)(sic)(sic)40.0(sic)(sic)),(sic)(sic)(sic)(sic)/(sic)(sic),(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic).(sic)(sic) (sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)25.0%((sic)(sic)(sic)(sic)(sic)[IQR], 15.5-36.3), (sic)PGA(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)12.6%(IQR, 9.2-17.9)(p=0.0019).(sic)(sic)(sic)(sic)(sic)(sic)(sic), PGA(sic)(sic)(sic)(sic)(p=0.0015)(sic)(sic)(sic)(sic)(sic)(p=0.0056)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic).PGA(sic)(sic)(sic)(sic)(sic)(sic)(sic)(21.4% vs. 8.0%)(sic)(sic)(sic)(sic)(sic)(sic)(32.1% vs. 8.0%, p=0.043)(sic)(sic)(sic)(sic)(sic).(sic)(sic)(sic)(sic)(sic) (sic)(sic)(sic)(sic)(sic)(sic)cT1-2(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic), (sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic).(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic), PGA(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic), (sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic).

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