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Anidulafungin Treatment of Candidal Central Nervous System Infection in a Murine Model
- Kang, Cheol-In;
- Rouse, Mark S.;
- Mandrekar, Jayawant N.;
- Steckelberg, James M.;
- Patel, Robin
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14초록
We established a murine model of Candida albicans central nervous system (CNS) infection and evaluated the efficacy of anidulafungin. Ten milligrams/kg/day anidulafungin, amphotericin B, or voriconazole significantly reduced mortality and fungal burden in brain tissue, although amphotericin B and 10 mg/kg/day anidulafungin reduced fungal burden in brain tissue to a greater extent than did voriconazole. This suggests a potential role for anidulafungin in the treatment of candidal CNS infection.
키워드
CLINICAL-TRIALS; AMPHOTERICIN-B; VORICONAZOLE; CANDIDIASIS; PHARMACOKINETICS; ECHINOCANDIN; CASPOFUNGIN; MICAFUNGIN; EFFICACY
- 제목
- Anidulafungin Treatment of Candidal Central Nervous System Infection in a Murine Model
- 저자
- Kang, Cheol-In; Rouse, Mark S.; Mandrekar, Jayawant N.; Steckelberg, James M.; Patel, Robin
- 발행일
- 2009-08
- 유형
- Article
- 권
- 53
- 호
- 8
- 페이지
- 3576 ~ 3578