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Aven overexpression: Association with poor prognosis in childhood acute lymphoblastic leukemia
- Choi, Jaewon;
- Hwang, Yu Kyeong;
- Sung, Ki Woong;
- Kim, Dong Hyun;
- Yoo, Keon Hee;
- 외 2명
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22초록
Aven expression has recently been identified as an anti-apoptotic protein. In this study, Aven expression in 91 children with acute lymphoblastic leukemia (ALL) was investigated for possible correlation with clinical features at diagnosis and treatment outcome. Aven expression was found to be higher in patients >= 10 years old or < 1 year (P=0.003), and in patients with unfavorable cytogenetic abnormalities (P < 0.001). Aven expression was also significantly higher in relapsed patients in the standard-risk group. Aven overexpression was an independent poor Prognostic factor. These findings demonstrate that Aven expression can predict prognosis in childhood ALL. (c) 2005 Elsevier Ltd. All rights reserved.
키워드
Aven; apoptosis; acute lymphoblastic leukemia; prognostic factors; quantitative RT-PCR; children; CHILDRENS CANCER GROUP; CELL APOPTOSIS; RISK; SURVIVIN; EXPRESSION; CHROMOSOMES; INHIBITOR; CASPASES; ONCOLOGY; FEATURES
- 제목
- Aven overexpression: Association with poor prognosis in childhood acute lymphoblastic leukemia
- 저자
- Choi, Jaewon; Hwang, Yu Kyeong; Sung, Ki Woong; Kim, Dong Hyun; Yoo, Keon Hee; Jung, Hye Lim; Koo, Hong Hoe
- 발행일
- 2006-08
- 유형
- Article
- 권
- 30
- 호
- 8
- 페이지
- 1019 ~ 1025