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Mutations in <i>gyrA</i> and <i>gyrB</i> in Moxifloxacin-Resistant <i>Mycobacterium</i> <i>avium</i> Complex and <i>Mycobacterium</i> <i>abscessus</i> Complex Clinical Isolates
- Kim, Su-Young;
- Jhun, Byung Woo;
- Moon, Seong Mi;
- Shin, Sun Hye;
- Jeon, Kyeongman;
- ... Huh, Hee Jae;
- ... Suh, Gee Young;
- 외 7명
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WEB OF SCIENCE
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SCOPUS
30초록
Data on the frequency of gyrA and gyrB mutations in fluoroquinolone-resistant isolates of the Mycobacterium avium complex (MAC) and the Mycobacterium abscessus complex (MABC) are limited. In our analysis, we did not find any resistance-associated mutations in gyrA or gyrB in 105 MAC or MABC clinical isolates, including 72 moxifloxacin-resistant isolates. Our findings suggest that mechanisms other than gyrA and gyrB mutations contribute to moxifloxacin resistance in these organisms.
키워드
Mycobacterium avium complex; Mycobacterium abscessus complex; moxifloxacin; resistance; gyrase mutation; PULMONARY-DISEASE; LUNG-DISEASE; DNA GYRASE; ANTIMICROBIAL SUSCEPTIBILITY; FLUOROQUINOLONE RESISTANCE; QUINOLONE RESISTANCE; TREATMENT OUTCOMES; TUBERCULOSIS; POLYMORPHISMS; MECHANISMS
- 제목
- Mutations in <i>gyrA</i> and <i>gyrB</i> in Moxifloxacin-Resistant <i>Mycobacterium</i> <i>avium</i> Complex and <i>Mycobacterium</i> <i>abscessus</i> Complex Clinical Isolates
- 저자
- Kim, Su-Young; Jhun, Byung Woo; Moon, Seong Mi; Shin, Sun Hye; Jeon, Kyeongman; Kwon, O. Jung; Yoo, In Young; Huh, Hee Jae; Ki, Chang-Seok; Lee, Nam Yong; Shin, Sung Jae; Daley, Charles L.; Suh, Gee Young; Koh, Won-Jung
- 발행일
- 2018-09
- 유형
- Article
- 권
- 62
- 호
- 9
- 언어
- ENG
- 출판사
- American Society for Microbiology
- ISSN
- E 1098-6596
P 0066-4804