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초록
We conducted a hospital-based case-control study in Korea to investigate whether apoptosis-and cell cycle control-related genes are associated with childhood brain tumor. Incident brain tumor cases (N = 70) and non-cancer controls (N = 140), frequency-matched by age and gender, were selected from 3 teaching hospitals in Seoul between 2003 and 2006. Tag single nucleotide polymorphisms (SNPs) (N = 297) in 30 genes related to apoptosis and cell cycle control were selected using a pairwise linkage-disequilibrium- based algorithm. Five tag SNPs in 2 genes (AICDA and CASP14) remained significant after adjusted multiple tests. The most significant association with childhood brain tumor risk was for IVS1-401G>C in the AICDA gene [odds ratio (OR) = 2.8; 95% confidence interval (95% CI) = 1.25-6.46]; the polymorphism *9276A> C of CASP14 was associated with decreased brain tumor risk (OR = 0.4; 95% CI = 0.19-0.95). We concluded that genetic polymorphisms in AICDA and CASP14 are associated with risk for brain tumor in Korean children.
키워드
- 제목
- Genetic variants of <i>AICDA</i>/<i>CASP14</i> associated with childhood brain tumor
- 저자
- Jeon, S.; Han, S.; Lee, K.; Choi, J.; Park, S. K.; Park, A. K.; Ahn, H. S.; Shin, H. Y.; Kang, H. J.; Koo, H. H.; Seo, J. J.; Choi, J. E.; Kim, H.; Ahn, Y.; Kang, D.
- 발행일
- 2013-06
- 유형
- Article
- 권
- 12
- 호
- 2
- 페이지
- 2024 ~ 2031