Association between body weight time in target range and risk of type 2 diabetes in adults with obesity

초록

Background Obesity is a major risk factor for type 2 diabetes, underscoring the need for effective weight management strategies for its prevention and control. We evaluated the association between body weight time in target range (TTR) and the risk of type 2 diabetes in adults with obesity. Methods Using the 2010-2022 Korean National Health Insurance Service database, we included 248,367 adults with obesity with no history of diabetes. Body weight TTR was defined as the proportion of time maintaining a >= 3% reduction from baseline body weight. Participants were categorized into body weight TTR groups: 0%, > 0-50%, and > 50-100%. The primary outcome was the incidence of type 2 diabetes. Cox proportional hazards models were used. Results Over a median follow-up of 5.6 years, 46,737 participants (18.8%) developed type 2 diabetes. Individuals with body weight TTR > 0-50% and > 50-100% had significantly lower risk of type 2 diabetes compared with individuals with body weight TTR = 0%, with adjusted hazard ratios (aHR) of 0.86 (95% confidence interval [CI]: 0.84-0.88) and 0.66 (95% CI: 0.64-0.67), respectively. Each 10% increase in body weight TTR was significantly associated with a lower risk of type 2 diabetes (aHR: 0.95, 95% CI: 0.95-0.96). Five-year absolute risks declined across body weight TTR groups: 12.82%, 11.10%, and 8.62%. Conclusion Among adults with obesity, a higher body weight TTR was significantly associated with a reduced risk of developing type 2 diabetes, highlighting the importance of sustained weight management in diabetes prevention.

키워드