The relationship between estimated average glucose and fasting plasma glucose

초록

Background: Estimated average glucose (eAG) is a value calculated from hemoglobin A(1c) (HbA(1c)) that reflects average glycemic status over the preceding few months. A linear relationship between HbA(1c) and eAG was demonstrated by the International HbA(1c)-Derived Average Glucose (ADAG) Trial in 2008. We investigated the relationship between fasting plasma glucose (FPG) and eAG. Methods: This retrospective study was conducted by reviewing the medical records of 6443 subjects, including 5567 diabetic patients and 876 non-diabetic subjects. The levels of HbA(1c) and FPG were reviewed and eAG was calculated using the regression equation published by the ADAG trial: eAG(mmol/L) = 1.59 x HbA(1c) (NGSP, %)-2.59[eAG (mg)/(dL) = 28.7 x HbA(1c) (NGSP, %)-46.7]. Results: In all subjects, FPG showed a moderate correlation with eAG (r = 0.672, p<0.001). When diabetic and non-diabetic subjects were divided into subgroups according to FPG level, the correlation between eAG and FPG decreased in both diabetic [FPG = 10.0 mmol/L (180 mg/dL), r = 0.425; FPG 7.2-9.9 mmol/L (130-179 mg/dL), r = 0.373; FPG<7.2 mmol/L (130 mg/dL), r = 0.202] and non-diabetic [FPG 5.6-6.9 mmol/L (100-125 mg/dL), r = 0.363; FPG<5.6 mmol/L (100 mg/dL), r = 0.186] subgroups as the FPG level decreased. The differences between eAG and FPG were statistically significant (p<0.001). Only 81% (4487/5567) of diabetic patients had a lower FPG level than eAG level. Conclusions: Our results suggest that the relationship between eAG and FPG may depend on glycemic control, thereby enhancing our understanding of eAG.

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