Outcomes After Curative Hepatectomy in Patients with Non-B Non-C Hepatocellular Carcinoma And Hepatitis B Virus Hepatocellular Carcinoma From Non-Cirrhotic Liver

초록

Backgrounds and ObjectiveThere is controversy regarding liver function of non-B, non-C hepatocellular carcinoma (NBNC-HCC) patients, the biological behavior of their tumors, and the outcome after surgical treatment. The aims of the present study were to compare clinicopathologic data and long-term clinical outcomes between NBNC-HCC patients and hepatitis B virus HCC (HBV-HCC) patients from non-cirrhotic liver after curative hepatectomy. MethodsData for HBV-HCC patients (n=360) and NBNC-HCC patients (n=103) were retrospectively reviewed. ResultsThe median age of patients in the NBNC group was significantly higher than that of the HBV group (63 years vs. 53 years, P<0.001). Tumor size in the NBNC group was greater than that in the HBV group (5.1cm vs. 3.8cm, P<0.001). Regarding liver histology, the grade of lobular activity, periportal activity, and fibrosis in the HBV group was higher than in the NBNC group (P<0.001, P<0.001, and P<0.001, respectively). There were no statistically significant differences in disease-free survival and overall survival between the two groups (P=0.257 and P=0.579, respectively). Multivariate analysis showed that increased tumor size, microvascular invasion, and intrahepatic metastasis were associated with tumor recurrence after curative liver resection. ConclusionFor patients with non-cirrhotic liver, clinical outcomes for NBNC-HCC were comparable to those for HBV-HCC after curative hepatectomy. J. Surg. Oncol. 2014; 110:976-981. (c) 2014 Wiley Periodicals, Inc.

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